小鼠抗rybp单ke隆抗体

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ground:

the products of the polycomb group (pcg) of genes are necessary for the maintenance of tranional repression of a number of important developmental genes, including the homeotic genes. rybp is a member of the mammalian polycomb complex. rybp (ring1-&yy1-binding protein) interacts specifically with the e2f2&e2f3 family members, dependent on the marked box domain in these proteins. yy1&rybp, in combination with either e2f2/e2f3, can stimulate cdc6 promoter activity synergistically, at g1/s of the cell cycle. rybp also complexes with both ring1 proteins (ring1&ring1b)&with m33, two mutually interacting sets of proteins of the mammalian polycomb complex. ring1 binds rybp&m33 through the same c-terminal domain, whereas the rybp-m33 interaction takes place through an m33 domain not involved in binding. rybp is widely expressed with highest levels in lymphoid tissues&placenta.

applications:

wb

name of an

tibody:

rybp

immunogen:

fusion protein of human rybp

full name:

ring1&yy1 binding protein (rybp)

synonyms:

aap1; dedaf; yeaf1; apap-1

swissprot:

q8n488

wb predict

ed band size:

25 kda

wb positiv

e control:

hela, svt2, a549, cos7, jurkat, mdck cell lysates

wb recom

mended dilution:

500-2000